Baricitinib reaching out for the market

It seems that baricitinib gets ready to come to the market. The annual meetings this year have seen a plethora of studies on baricitinib both at the EULAR meeting in London and the ACR meeting in Washington.

Noteworthy: both meetings received different studies or better different aspects of studies. With other compounds abstracts didn’t differ at both congresses. Not so with baricitinib.

Interestingly the crucial study on radiographic progression only appeared at the EULAR meeting. The FDA approved tofacitinib, but EMEA didn’t a couple of years ago. I think this had an impact on baricitinib. If it had an impact on FDA, let’s wait to see if baricitinib is approved or not. Tofacitinb has applied for approval in Europe (March 2016), so Xeljanz should have an advantage of time.

The study by D. van der Heijde and colleagues showed a robust inhibition of radiographic progression for the 4 mg dose of baricitinib.

N.V. Zamora and colleagues came to the following conclusions: 1. baricitinib with or without MTX had better responses as compared to MTX at 12 and 24 weeks (baricitinib+MTX lower withdrawal rate than MTX alone), 2. baricitinib showed similar effects as adalimumab (with higher rates of SAEs). The authors consider baricitinib to be an additional therapeutic option to treat patients with moderate to severe rheumatoid arthritis, who have an inadequate response to other treatment agents.

There will be a study in a few days by Kevin L. Winthrop and colleagues at the ACR Annual Meeting in Washington: “Herpes Zoster in Patients with moderate to Severe Rheumatoid Arthritis Treated with Baricitinib” [Abstract Number: 3027] – which will have to be discussed at the meeting first.

What can we say today? Lilly is committed to bring baricitinib to the market. Let’s see how quickly. I expect approval or non-approval within half a year both for the US and the EU.

Links:

Radiographic progression – EULAR [THU0168] D. van der Heijde , M. Dougados , Y.-C. Chen, M. Greenwald , E. Drescher , R. Klar , L. Xie , I. de la Torre , T.P. Rooney , S. Witt , D. Schlichting , S. DeBono, P. Emery: Baricitinib Inhibits Radiographic Progression of Structural Joint Damage at 1 Year in Patients with Rheumatoid Arthritis (Ra) and an Inadequate Response to csDMARDS. DOI: 10.1136/annrheumdis-2016-eular.1611

Meta-Analysis - EULAR [SAT0177] N.V. Zamora , J. Tayar , M.A. Lopez-Olivo , R. Christensen , M.E. Suarez-Almazor: Baricitinib for  Rheumatoid Arthritis: A Systematic Review and Meta-Analysis. DOI: 10.1136/annrheumdis-2016-eular.4449

FreitagsGedichte / Kurze Gedichte 11.11.2016

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Festival of San Lucas (St. Luke) at Toconao

I had the good luck of being in Toconao at the time of the festival of the village saint San Lucas (St. Luke, the physician and writer of the 3^rd gospel as well as the book Acts of the Apostles). 

Toconao is a village at 2,485 m (8,153 ft) in Chile, south of San Pedro de Atacama. The region is a desert, but Toconao is an oasis because of a stream of pure water. In 2006 the village had less than 800 inhabitants. “The most notable building in Toconao is its church [Iglesia de San Lucas]. The bell tower is separated from the main church structure and dates from 1750.” Says Wikipedia. And the festival of the patron of the village is in October (18.10.).

The dancers hardly get a break. And one of the bands already look like having played in the movie “They shoot horses, don’t they”. It’s more than what we see at carnival in Cologne. You need stamina. In between dancing to praise San Lucas, the dancers enter church and pray there. The nuns there pray, too, and talk about the saint. The village doesn’t have a steady priest, but of course someone is visiting the village regularly as only a priest can consecrate the host, which is kept afterwards in the tabernacle. 

You might get the impression when looking at dancing to praise a saint as a thin roman-catholic layer on folk believes in South America, but you will find worldwide some non-Christian folk religion having entered Christianity. Or do you think that the Christmas tree has a Christian origin?

You might think that the people look rather Bolivian, which isn’t so far from the truth. The region had been a part of Bolivia until Chile won the War of the Pacific in 1884 and the area has been part of Chile since then or better after signing the peace treaty in 1904, or even as late as 1929. But that's better discussed on a history blog. Bolivia still claims access to the Pacific Ocean.

The Stream that nurtures Toconao

 

 

Ball Tower and Church in the background

 

 

Dancers - the biggest group

 

 

Sultans of Brass

 

 

The colored squares on the dresses resemble the new flag of Bolivia

 

 

Dancing is fun, too

 

 

Not as unusual as you might think ...

 

... have a look at this announcement in La Paz (Bolivia) for a folklore ballet staged by the catholic university of San Pablo

 

Links:

https://en.wikipedia.org/wiki/Toconao

https://es.wikipedia.org/wiki/Toconao

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